哺乳动物大脑中 GABAB 受体的特性及其可塑性
On the nature of GABAB receptors and their plasticity in the mammalian brain
这篇综述比较了 GABAB 受体在不同细胞类型、脑区和哺乳动物物种间的表达与调控证据，重点关注其可塑性机制及与癫痫、痴呆等神经系统疾病的关系。GABAB 受体在神经元突触前和突触后区域产生强抑制，却常被忽视；其功能受多样化磷酸化及多种辅助亚基相互作用的调节。
Gamma-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter of the mammalian CNS, essential for circuit function and behaviour. In the brain, GABA activates GABAA and GABAB receptors to modulate circuit activity on behaviourally relevant timescales. GABAB receptor signalling in pre- and postsynaptic domains of neurons is often overlooked, despite the strong inhibition it produces. Importantly, GABAB receptors are diversely phosphorylated and interact with various auxiliary subunits to modify function. This review compares the evidence for the expression and modulation of GABAB receptors, their effectors, and regulatory mechanisms between cell types, brain areas, and mammalian species, particularly focusing on the plasticity of these mechanisms and their relationship to neurological diseases such as epilepsy and dementia.
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来源：Trends in Neurosciences · cell.com