Neuron· Dan Dai, Boyan Zhang, Xiaoxi Zhang, Shiting Chen, Li Sun, Hui Yang, Jinfei Ni, Shumin Duan·· 2026-09-11AI 评分62
Neuron：下丘脑—迷走通路介导应激性摄食抑制与胃功能紊乱
A hypothalamic-vagal pathway mediates stress-induced feeding suppression and gastric dysfunction
AI 导读
依据摘要，Dai 等人在下丘脑室旁核中识别出表达神经肽 Y 受体 Y1 的应激响应神经元，这些神经元连接背侧迷走复合体，抑制摄食并延迟胃排空。抑制该通路可缓解上述应激诱导的反应，提示存在一条协调急性应激下摄食与胃功能的下丘脑—脑干环路。该结果来自动物研究，具体样本量、效应量与实验设计未在摘要中报告，是否适用于人类仍需进一步研究。
摘要
Dai et al. identify stress-responsive neuropeptide Y receptor Y1-expressing neurons in the hypothalamic paraventricular nucleus that engage the dorsal vagal complex to suppress feeding and delay gastric emptying. Inhibiting this pathway alleviates these stress-induced responses, revealing a hypothalamic-brainstem circuit coordinating feeding and gastric function during acute stress.
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来源：Neuron · cell.com