Neuron· Ruicheng Dai, Wenting Wu, Xiangyu Zhou, Yu Zhou, Xinwei Gao, Minmin Luo·· 2026-09-28AI 评分70
小胶质细胞SPP1-ITGB1反馈环路维持丘脑过度兴奋与卒中后疼痛
A microglial SPP1-ITGB1 feedback loop sustains thalamic hyperexcitability and post-stroke pain
AI 导读
Dai 等人在丘脑出血模型中识别出一条小胶质细胞骨桥蛋白（SPP1）-整合素β1反馈程序，该程序维持机械性痛觉超敏。依据摘要，遗传学和药理学实验将 CC 趋化因子信号置于骨桥蛋白下游，并显示广泛抑制 CC 趋化因子可同时减轻痛觉超敏和病灶周围神经元过度兴奋。研究提示该反馈环路是卒中后疼痛的潜在干预靶点，但结果来自动物模型，是否适用于人类仍需验证。
摘要
Dai et al. identify a microglial osteopontin (SPP1)-integrin β1 feedback program that sustains mechanical allodynia after thalamic hemorrhage. Genetic and pharmacological experiments place CC-chemokine signaling downstream of osteopontin and show that broad CC-chemokine inhibition reduces both allodynia and peri-lesional neuronal hyperexcitability.
中文翻译还没有生成，先显示原文。
来源：Neuron · cell.com