习惯性睡眠时长与脑网络可控性的皮层组织有关
Habitual sleep duration is associated with the cortical organisation of brain network controllability
习惯性睡眠如何与支持脑状态灵活转换的结构网络属性相关，目前仍不清楚。研究把腕表加速度计睡眠测量与弥散磁共振连接组结合，纳入 15,799 名英国生物银行成年人，发现工作日睡眠更长与感觉运动系统的模态可控性更高、视觉皮层可控性更低有关，该模式在 4,740 人的锁定测试集中重现。分解显示这反映结构连接权重的重新分配，周末补觉未见类似关联；该模式与脑老化模式不同，在 1,226 个表型中主要与体力活动和身体成分有关，而非认知。
Sleep is fundamental to adaptive brain function, yet how habitual sleep relates to the structural network properties that support flexible transitions between brain states remains poorly understood. Combining wrist-accelerometer sleep measures with diffusion MRI connectomes from 15,799 UK Biobank adults, we show that longer workday sleep is associated with higher modal controllability of somatomotor systems and lower controllability of visual cortex. This system-specific signature reproduced in a locked test set (n = 4,740) and was robust across extensive sensitivity analyses. Decomposition showed that it reflects a redistribution of structural connection weight, with greater absolute visual connectivity and a smaller somatomotor share of the whole-brain total. Weekend catch-up sleep showed no comparable association. The signature was distinct from brain-ageing patterns and, across 1,226 phenotypes, related mainly to physical activity and body composition rather than cognition. These findings link everyday sleep habits to the system-specific organisation of brain network controllability.
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来源：bioRxiv · Neuroscience · biorxiv.org