重建差异与果蝇罗盘连接组的个体差异相当，并使训练好的环路模型失效
Reconstruction differences rival individual differences in the fly compass connectome and break trained circuit models
arXiv:2610.29205v2 公告类型：替换 摘要：神经网络模型越来越多地基于突触分辨率连接组构建，而同一神经环路如今也可从其他动物和流程的重建中获得。我们尚不清楚此类模型是否依赖于其所基于的重建，也不清楚连接组差异是生物学差异还是测量误差。我们以九个版本研究了果蝇头方向环路：四只果蝇（雄性 CNS、hemibrain、FlyWire、BANC）以及同一只果蝇的五个变体，这些变体仅在阈值、校对或突触检测上有所不同。利用经解剖标签验证的基于连接关系的对应关系，我们将所有差异置于同一尺度上。在同一只果蝇内改变突触检测，在四项距离度量上使环路的变化超过最小果蝇间差异的一半；校对差异较小，但取决于度量指标，而同一只果蝇的左右两半之间的差异不超过随机两半。基于每种连接训练以保持提示朝向的网络形成了近乎完美的环形吸引子，但当所有权重改变 1% 时，其误差从低于 1 度增加到 10-28 度。基于每种连接进行的训练均无法迁移到任何其他连接组，包括同一只果蝇的其他版本；重新拟合三十个细胞类型增益后，我们修复了滤波层面的差异，但剩余误差取决于连接距离。带噪声训练降低了精度，且仅带来部分迁移。在成像数据中，果蝇罗盘在黑暗中逐渐漂移。受连接组约束的模型应报告其所基于的重建，并应测试其在各重建之间的稳健性。
把同一环路的多套连接组重建放在同一尺度上比较，说明基于连接组训练的模型对重建来源高度敏感。
arXiv:2610.29205v2 Announce Type: replace Abstract: Neural network models are increasingly constructed from synapse-resolution connectomes, and the same circuit is now available in reconstructions from other animals and pipelines. We do not know whether such models are dependent on the reconstruction they are built from, and whether connectome differences are biological or measurement errors. We studied the Drosophila head-direction circuit in nine versions: four flies (male CNS, hemibrain, FlyWire, BANC) and five variants of the same fly varying only by thresholds, proofreading or synapse detection. Using wiring-based correspondences validated by anatomical labels, we place all differences on one scale. A change of synapse detection within one fly changed the circuit more than halfway to the smallest between-fly difference on four distance measures; proofreading differences were smaller but depended on the metric, and left and right halves of one fly differed no more than random halves. Networks trained on each wiring to hold a cued heading developed near-perfect ring attractors, but their error increased from below 1 degree to 10-28 degrees when all weights changed by 1%. Training on each wiring did not transfer to any other connectome, including other versions of the same fly; refitting thirty cell-type gains, we repaired filtering-level differences but remaining error depended on wiring distance. Training with noise lowered precision and gave only partial transfer. In imaging data, the fly compass drifted gradually in darkness. Connectome-constrained models should report the reconstruction they were built on and be tested for robustness across reconstructions.
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来源：arXiv · Neural and Evolutionary Computing · arxiv.org