Neuron· Zongming Chen, Mengting Wang, Jialiang Xue, Zhiwei Li, Yinuo Chen, Dandan Zhou, Hongcheng Tu, Hanying Zhuang, Haoran Du, Yuxin Chen, Xinyan Ni, Jianbao Wang, Tao Li, Hongbin Yang, Zhengdong Zhao, Wei L. Shen·· 2026-09-22AI 评分65
小鼠暴食症模型：aZI 到 VTA 环路驱动强迫性进食
Anterior zona incerta to ventral tegmental area circuit controls compulsive eating in a binge-eating-disorder mouse model
AI 导读
依据 Neuron 刊发的摘要，Chen 等在小鼠暴食症模型中识别出前部未定带（aZI）神经元是强迫性暴食的关键驱动因素。间歇性高脂饮食暴露提高 GABA 能 aZI 神经元兴奋性，通过直接和间接环路增强中脑边缘多巴胺信号，驱动抗厌恶的强迫性暴食；Nrsn2 标记的 aZI 神经元群为暴食症发展所必需。上述结果为动物模型中的环路机制发现，是否适用于人类仍需进一步研究。
摘要
Chen et al. identify anterior zona incerta aZIT neurons as key drivers of compulsive binge eating. Intermittent high-fat-diet exposure increases GABAergic aZIT neuronal excitability, thus enhancing mesolimbic dopamine signaling through direct and indirect circuits and driving aversion-resistant compulsive binge eating. Nrsn2 marks the aZI neuronal population required for BED development.
中文翻译还没有生成，先显示原文。
来源：Neuron · cell.com