Neuron· Wenying Xu, Jiu-Yang Sun, Chunguang Chu, Xin Yi, Sheng-Jie Lin, Shuai-Yu Wang, Jing-Xue Liang, Yan-Jiao Wu, Yong-Ling Wang, Xin-Ni Li, Ying-Xiao Liu, Yi Lv, Junfa Wu, Bomin Sun, Tian-Le Xu, Zhenguo Liu, Lu Song, Wei-Guang Li·· 20 天前AI 评分62
前扣带回集群的分阶段参与与慢性疼痛中的动机下降有关
Stepwise engagement of cingulate ensembles underlies motivational decline in chronic pain
AI 导读
依据期刊摘要，Xu、Sun 等人在雄性小鼠中报告，神经病理性疼痛分阶段调动前扣带回的输出通路：投射到杏仁核的神经元参与早期机械性超敏，而投射到缰核的神经元参与后期努力坚持能力的受损。研究提示，前扣带回—杏仁核的往复信号可能是连接这两个阶段的候选通路。该结果来自动物模型，是否适用于人类慢性疼痛及其动机症状仍需进一步研究。
摘要
Xu, Sun, et al. show that neuropathic pain engages anterior cingulate outputs in stages in male mice. Amygdala-projecting neurons contribute to early mechanical hypersensitivity, whereas habenula-projecting neurons contribute to late impairment of effortful persistence. Recurrent cingulate-amygdala signaling offers a candidate route between these stages.
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来源：Neuron · cell.com