Trends in Neurosciences· Annemarie J. Carver, Nicole R. Zürcher, Evan A. Bordt·· 23 天前AI 评分62
小胶质细胞生物钟在神经发育期塑造突触
A microglial circadian clock sculpts synapses during neurodevelopment
AI 导读
依据摘要，Routh 等在小鼠研究中发现，生物钟调控小胶质细胞主导的神经发育关键期突触修剪，且存在性别差异。在小胶质细胞中敲除主要生物钟调控因子 Bmal1 会诱导促炎状态和突触过度修剪，主要见于青春期雄性小鼠。该结果提示免疫细胞的昼夜节律可能影响发育期突触连接，但研究为小鼠模型，是否适用于人类仍需进一步验证。
摘要
In a recent study, Routh and colleagues demonstrated that the circadian clock regulates microglia-directed synaptic refinement during a critical period of neurodevelopment in mice, in a sex-dependent manner. Loss of the major circadian rhythm regulator, Bmal1, in microglia induced a proinflammatory state and excessive pruning of synapses, primarily in adolescent male mice.
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来源：Trends in Neurosciences · cell.com