Neuron· Wen Zhang, Xi Zha, Huateng Cao, Liping Gong, Liu Fan, Zhitao Feng, Zhewei Zhang, Xuanzi Cao, Yunxian Bai, Xiaojing Ding, Mengtong Gao, Zhuolei Jiao, Shuaishuai Li, Ziyue Wang, Qian Zhang, Tianming Yang, Huatai Xu, Zhe Zhang, Yuanyuan Mi, Xiaohong Xu·· 2026-09-17AI 评分62
Neuron：小鼠mPOA抑制后反弹放电将抑制转化为兴奋，促进雄性交配启动
Post-inhibitory rebound firing promotes hypothalamic activation during male mating in mice
AI 导读
依据期刊摘要，Zhang 等在小鼠中发现，内侧视前区（mPOA）由 T 型钙通道介导的抑制后反弹放电，可将抑制性输入转化为兴奋性活动，从而促进雄性交配中爬跨行为的启动。研究关注的是：抑制性输入与 mPOA 激活均为雄性交配所需，但抑制如何在爬跨期间贡献神经元活动此前并不清楚。该结果提示抑制后反弹放电是 mPOA 环路中一种把抑制转为兴奋的机制，属动物研究，是否适用于其他物种与行为尚待验证。
摘要
Both inhibitory inputs to the mPOA and mPOA activation are required for male mating, but how inhibition contributes to neuronal activity during mounting remains unclear. Zhang et al. identify T-type calcium channel-mediated post-inhibitory rebound firing in the mPOA as a mechanism that converts inhibition into excitation to facilitate mount initiation.
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来源：Neuron · cell.com