Neuron· Dong Dong, Jiantao Huo, Guangjuan Yin, Kaifang Duan, Kaiyuan Hu, Dongmei Su, Xi Liu, Changyi Zhang, Shujia Zhu, Tanhan Xiang, Ruolin Wang, Changlin Li, Chao Guo, Minshi Chen, Longzhen Cheng·· 2026-09-03AI 评分62
Neuron：小鼠下行甘氨酸能环路经脊髓 GluN3A 受体驱动阿片耐受性机械痛
A descending glycinergic circuit drives opioid-resistant mechanical pain via spinal GluN3A excitatory glycine receptors in mice
AI 导读
依据摘要，Dong 等在小鼠中鉴定出一条从脑干下行至脊髓的神经环路，该环路驱动广泛且对阿片类药物不敏感的疼痛。研究显示，这条通路释放的甘氨酸在脊髓中作为兴奋性信号，通过激活一类特定的 NMDA 受体（GluN3A 兴奋性甘氨酸受体）起作用，从而揭示了一种此前未知的难治性触觉痛机制。材料仅为摘要，未提供样本量、实验设计与效应量等细节，结论基于小鼠研究，是否适用于人类仍需进一步验证。
摘要
Dong et al. identify a descending brainstem-to-spinal-cord circuit that drives widespread, opioid-resistant pain in mice. They show that glycine from this pathway acts as an excitatory signal by activating a specific type of NMDA receptor in the spinal cord, revealing a previously unknown mechanism for refractory tactile pain.
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来源：Neuron · cell.com