不同的毫秒级点击串模式在人与大鼠中诱发可区分的行为与神经反应
Distinct millisecond-scale click-train patterns evoke discriminable behavioral and neural responses in humans and rats
作者：翟玉英、宋培润、Ana Belén Lao-Rodríguez、杜欣宇、徐浩轩、叶航婷、鲍雪慧、Ishrat Mehmood、Nayaab Shahir Pandit、常诚、戴周游、涂志毅、陈培、张婷婷、张玲玲、赵璇、David Pérez-González、Manuel S. Malmierca、余雄杰。自然声音由频谱内容和时间模式共同塑造。本文探究：在平均点击间隔相同、但毫秒级时间模式不同的情况下，点击串是否会诱发不同的行为和神经反应。人类听者能够辨别若干此类点击串模式，人类 EEG 显示出依赖情境的偏差相关反应。清醒大鼠在 ECoG 水平上表现出类似的皮层反应差异。沿 IC–MGB–A1 通路，单元记录显示 IC 的 oddball/情境敏感性较弱，MGB 为中等敏感性，而 A1 具有更强的刺激特异性适应。可逆性失活听觉皮层降低了 MGB 的敏感性，表明存在皮层-丘脑反馈的贡献。进一步的 A1 分层分析显示，浅层（supragranular）效应强于深层皮层。总之，这些结果表明，不同的点击串时间模式在听觉系统中具有差异化的表征，且更强的敏感性出现在更高的听觉结构中。
用平均间隔相同、毫秒级时间构型不同的点击串，把时间模式敏感度沿IC–MGB–A1逐级定位，并给出皮层反馈参与的证据。
by Yuying Zhai, Peirun Song, Ana Belén Lao-Rodríguez, Xinyu Du, Haoxuan Xu, Hangting Ye, Xuehui Bao, Ishrat Mehmood, Nayaab Shahir Pandit, Cheng Chang, Zhouyou Dai, Zhiyi Tu, Pei Chen, Tingting Zhang, Lingling Zhang, Xuan Zhao, David Pérez-González, Manuel S. Malmierca, Xiongjie Yu Natural sounds are shaped by both spectral content and temporal patterning. Here we ask whether click trains with the same mean inter-click interval, but different millisecond-scale temporal patterns evoke distinct behavioral and neural responses. Human listeners discriminated several such click-train patterns, and human EEG revealed context-dependent deviance-related responses. Awake rats showed analogous cortical response differences at the ECoG level. Along the IC–MGB–A1 pathway, unit recordings revealed weak oddball/context sensitivity in IC, intermediate sensitivity in MGB, and stronger stimulus-specific adaptation in A1. Reversible inactivation of the auditory cortex reduced MGB sensitivity, indicating a contribution of corticothalamic feedback. Further A1 layer analyses showed stronger effects in supragranular than deep cortical layers. Together, these results show that distinct click-train temporal patterns are differentially represented across the auditory system, with stronger sensitivity emerging in higher auditory structures.
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来源：PLOS Biology · journals.plos.org